A team of researchers at the University of California, San Francisco (UCSF) has made a breakthrough discovery that could lead to new treatments for triple-negative breast cancer (TNBC). TNBC is a rare and aggressive form of breast cancer that is difficult to treat and has a poor prognosis.
The researchers found that TNBC cells are highly dependent on a protein called CDK4/6. By blocking CDK4/6 activity, the researchers were able to kill TNBC cells and shrink tumors in mice.
“This is a very exciting finding,” said Dr. Laura Esserman, the lead author of the study. “It is the first time that a specific weakness has been identified in TNBC cells. This gives us a new target for developing therapies.”
The researchers are now planning to begin clinical trials of CDK4/6 inhibitors in patients with TNBC. If the trials are successful, CDK4/6 inhibitors could become a new standard treatment for TNBC.
What is TNBC?
TNBC is a type of breast cancer that does not express the estrogen receptor, progesterone receptor, or HER2 protein. This makes it more difficult to treat than other types of breast cancer, as there are fewer targeted therapies available.
TNBC is also more likely to be aggressive and spread to other parts of the body. It is most common in younger women and women of color.
What is CDK4/6?
CDK4/6 is a protein that plays a role in cell growth and division. It is overexpressed in many types of cancer, including TNBC.
What is the significance of this research?
This research is significant because it has identified a new target for developing treatments for TNBC. CDK4/6 inhibitors are already approved for the treatment of other types of cancer, so they could be quickly brought to market for the treatment of TNBC.
What are the next steps?
The next steps are to begin clinical trials of CDK4/6 inhibitors in patients with TNBC. If the trials are successful, CDK4/6 inhibitors could become a new standard treatment for TNBC.
This research is a promising step towards developing new treatments for TNBC. CDK4/6 inhibitors could offer a new hope for patients with this aggressive form of breast cancer.